Connexin 43 signalling and cardioprotection
نویسندگان
چکیده
منابع مشابه
Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS). Molecular target therapy studies in MS have revealed that connexin-43 (Cx43) and Aquaporin-4 (AQP4) contents of astrocytes undergo expression alteration. Fluoxetine had some effects in MS patients unrelated to its known antidep...
متن کاملImpairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice.
Protection by ischemic preconditioning is lost in cardiomyocytes and hearts of heterozygous connexin 43 deficient (Cx43+/-) mice. Because connexin 43 (Cx43) is localized in cardiomyocyte mitochondria and mitochondrial Cx43 content is increased with ischemic preconditioning, we now tried to identify a functional defect at the level of the mitochondria in Cx43+/- mice by use of diazoxide and mena...
متن کاملConnexin 43 hemichannels are permeable to ATP.
Astrocytes are electrically nonexcitable cells that communicate by means of Ca(2+) signaling. Long-distance intercellular Ca(2+) waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does not exist. Here, through several altern...
متن کاملConnexin 43, E-cadherin, beta-catenin and ZO-1 expression, and aberrant methylation of the connexin 43 gene in NSCLC.
BACKGROUND The relationships between connexin 43 (Cx43) expression and clinicopathological factors, epithelial markers, and CpG island methylation in non-small cell lung cancer (NSCLC) are controversial. The aim of this study was to investigate whether the Cx43 expression related with clinicopathological factors, epithelial markers and methylation status of the Cx43 gene. PATIENTS AND METHODS...
متن کاملAstroglial connexin 43 sustains glutamatergic synaptic efficacy.
Astrocytes dynamic interactions with neurons play an active role in neurotransmission. The gap junction (GJ) subunits connexins 43 and 30 are strongly expressed in astrocytes and have recently been shown to regulate synaptic activity and plasticity. However, the specific role of connexin 43 in the morphological and electrophysiological properties of astrocytes in situ as well as in synaptic tra...
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ژورنال
عنوان ژورنال: Heart
سال: 2006
ISSN: 1355-6037
DOI: 10.1136/hrt.2005.066878